Quercetin and Resveratrol are Associated with the Downregulation of TNF-α/NF-kB/iNOS Axis-Mediated Acute Liver Injury in Rats Induced by Paracetamol Poisoning

Paracetamol (known as acetaminophen, or APAP) poisoning causes acute liver damage that can lead to organ failure and death. We sought determine APAP overdose augment tumor necrosis factor-alpha (TNF-α)/ nuclear factor kappa B (NF-kB)/induced nitic oxide synthase (iNOS) axis-mediated hepatotoxicity in rats, the anti-inflammatory polyphenolic compounds, quercetin (QUR) plus resveratrol (RES) ameliorate these parameters. Therefore, we induced rats using (2 g/kg, orally) protective group of were treated with 50 mg/kg QUR 30 RES for one week before ingestion. Animals killed at day 8. caused induction hepatic tissue levels TNF-α, NF-kB, iNOS, which significantly (p<0.05) decreased by QUR+RES. QUR+RES, also inhibited injury biomarkers, alanine aminotransferase (ALT) aspartate (AST). Additionally, a link between TNF-α /NF-kB / iNOS axis mediated was observed. Thus, presented data backing conclusion intoxication paracetamol increases NF-kB -mediated hepatotoxicity, is protected combination resveratrol.